diazepam and olopatadine intranasal equally increase sedation. Steer clear of or Use Alternate Drug. Coadministration improves chance of CNS melancholy, which can lead to additive impairment of psychomotor effectiveness and lead to daytime impairment.
C: Use with warning if Advantages outweigh challenges. Animal scientific studies clearly show chance and human reports not offered or neither animal nor human scientific tests finished.
Reserve concomitant prescribing of these medicines in people for whom other remedy selections are inadequate. Limit dosages and durations into the minimum amount demanded. Observe intently for indications of respiratory depression and sedation.
griseofulvin will lessen the level or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
diazepam will boost the degree or outcome of tinidazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
armodafinil will lessen the level or effect of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
fentanyl iontophoretic transdermal procedure and diazepam the two improve sedation. Stay away from or Use Alternate Drug. Restrict use to patients for whom different cure selections are insufficient
diazepam will increase the amount or outcome of midazolam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Coadministration of mild CYP3A4 inhibitors with midazolam intranasal might lead to larger midazolam systemic publicity, which can lengthen sedation.
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sage decreases effects of diazepam by pharmacodynamic antagonism. Insignificant/Importance Unknown. Theoretical conversation; some species of sage may result in convulsions.
triclabendazole will boost the stage or influence of diazepam by affecting hepatic enzyme CYP2C19 metabolism.
There are actually postmarketing experiences of coma and Demise with coadministration of buprenorphine and benzodiazepines. In many, although not most of these instances, buprenorphine was misused by self-injection. If a benzodiazepine must be useful for an indication in addition to seizures, decreased the benzodiazepine initial dose and cautiously titrate to scientific response.
lasmiditan, diazepam. Either increases consequences of another by sedation. Use Caution/Observe. Coadministration of lasmiditan along with other CNS depressant medicines, like alcohol have not been evaluated in medical studies. Lasmiditan may possibly cause sedation, along with other cognitive and/or neuropsychiatric adverse reactions.
diazepam and daridorexant both of those maximize sedation. Modify Therapy/Check Carefully. Coadministration will increase threat of CNS depression, which can lead to additive impairment of psychomotor overall performance and trigger daytime impairment.